Bicuculline

SKU: orb1304933

Description

Bicuculline

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 485-49-4
• MW: 367.35
• Purity: 99.99%
• Formula: C₂₀H₁₇NO₆
• SMILES: [H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]1([H])N(C)CCc2cc3OCOc3cc12
• Target: GABA Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.44 mM);DMSO:16.67 mg/mL (45.38 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  GABAA receptor:2 μM
• In Vivo:
  (+)-Bicuculline, at concentration of 1/3 μM, increase the EC50 of gamma-aminobutyric acid (GABA) by 1.6 times (41.0-67.0 μM) and by 3.6 times (36.1-129.0 μM), respectively This compound also dose-dependently inhibite the Cl- conductance induced by GABA (40 μM) in the range of 1-100 μM. In addition, (+)-Bicuculline inhibite the agonistic effects of GABA (40 μM) o the α1β2γ2L receptor, functioning as an antagonist o the α1β2γ2L GABAA receptor. This action caused a parallel shift in the concentration effect curve of GABA without affecting its maximum response. furthermore , (+)-Bicuculline also exhibited inhibitory effects on Ca2+ activated potassium channels.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Bicuculline, (+)-Bicuculline, AHP, alkaloid, d-Bicuculline, convulsant, competitive, inhibit, neurotransmitter, Inhibitor, GABAR, GABA Receptor, GABAReceptor, Gamma-aminobutyric acid Receptor, potassium, γ-Aminobutyric acid Receptor

Compound Identifiers

PubChem CID

10237