BI-7273

SKU: orb1300470

Description

BI-7273 is a potent and selective cell-permeable inhibitor of the BRD9 bromodomain. It is a valuable chemical probe for epigenetic research, enabling the study of BRD9 function in both cellular (in vitro) and animal (in vivo) models of cancer and inflammatory diseases.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1883429-21-7
• MW: 353.41
• Purity: 99.72% (May vary between batches)
• Formula: C₂₀H₂₃N₃O₃
• SMILES: COc1cc(cc(OC)c1CN(C)C)-c1cn(C)c(=O)c2cnccc12
• Target: Epigenetic Reader Domain
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:65 mg/mL (183.92 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.83 mM);Ethanol:65 mg/mL (183.92 mM)

Bioactivity

• Target IC50:
  BRD7:117 nM|BRD9:19 nM
• In Vitro:
  BI-7273 blocks EOL-1 cell proliferation with EC50 of 1400 nM. BI-7273 (1 μM) is active in U2OS cell lines. BI-7273 (10 μM) shows an inhibition below 40% against 31 kinases.
  Read more...
• Cell Research:
  Cells are grown in 50 μL medium as specified by the supplier for 7 days starting with 500 and with 1000 cells per well of a 384 well plate in the presence of varying concentrations of compound before measuring viability via cellular ATP levels using the cell titer glow assay.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRD9, BRD7, BI7273, BI-7273, BI 7273, Epigenetic Reader Domain, EpigeneticReaderDomain, Inhibitor, inhibit

Compound Identifiers

PubChem CID

118796358