dBRD9 HCl

SKU: orb1697558

Description

dBRD9 HCl is a PROTAC molecule that selectively degrades BRD9 with an IC50 of 56.6 nM in MOLM-13 cells, showing anti-proliferative activity in AML models. It is derived from the BRD9 ligand BI-7273 and the E3 ligase recruiter pomalidomide and exhibits high selectivity over BRD4 and BRD7.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2341840-98-8
• MW: 856.75
• Purity: 99.88% (May vary between batches)
• Formula: C₄₀H₄₇Cl₂N₇O₁₀
• SMILES: O=C1C2=C(C(C3=CC(OC)=C(CN(CC(NCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C)C(OC)=C3)=CN1C)C=CN=C2.Cl.Cl
• Target: Epigenetic Reader Domain,PROTACs
• Solubility: H2O:15.4 mg/mL (17.97 mM);DMSO:38.5 mg/mL (44.94 mM)

Bioactivity

• Target IC50:
  BRD9:56.6 nM
• In Vitro:
  dBRD9 (0.5-5000 nM; 4 h) reduces the expression of BRD9 in MOLM-13 cells in a concentration dependent manner with no significant effect on the expression of actin, BRD4, and BRD7. dBRD9 (100 nM; 2 hours) exhibits selectivity towards BRD9 in MOLM-13 cells. dBRD9 (7 days) exhibits anti-proliferative effects on EOL-1 and MOML-13 cell lines .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Epigenetic Reader Domain, EpigeneticReaderDomain, dBRD9 HCl, dBRD9 HCl(2170679-45-3 Free base), BRD9

Compound Identifiers

PubChem CID

138991768