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BI-4464

SKU: orb1301756

Description

BI-4464 is a potent and selective ATP-competitive inhibitor of PTK2/FAK, demonstrating an IC50 of 17 nM. This small molecule serves as a ligand for PROTAC development and is utilized in cancer research to study focal adhesion signaling in both cellular and animal models.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number1227948-02-8
MW555.55
Purity97.43% (May vary between batches)
FormulaC28H28F3N5O4
SMILESO(C1=C2C(CCC2=O)=CC=C1)C=3C(C(F)(F)F)=CN=C(NC4=C(OC)C=C(C(NC5CCN(C)CC5)=O)C=C4)N3
TargetFAK,Ligands for Target Protein for PROTAC
SolubilityDMSO:16.67 mg/mL (30.01 mM)

Bioactivity

Target IC50
PTK2/FAK:17 nM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BI 4464, BI4464, BI-4464, Focal adhesion kinase, FAK, inhibit, Inhibitor, Ligands for Target Protein for PROTAC, LigandsforTargetProteinforPROTAC, Target Protein-binding Moiety, PTK2, PTK2 protein tyrosine kinase 2, PTK2/FAK

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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

BI-4464 (orb1301756)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 mg
$ 80.00
5 mg
$ 120.00
10 mg
$ 160.00
25 mg
$ 260.00
50 mg
$ 370.00
100 mg
$ 490.00
200 mg
$ 680.00
DispatchUsually dispatched within 3-5 working days
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