BGG463

SKU: orb1302705

Description

BGG463 (K 0859) is a potent inhibitor of c-ABL-T334I, BCR-ABL, and the resistant BCR-ABL-T315I variant with respective IC50 values of 0.25, 0.09, and 0.590 µM. This compound is a valuable research tool for studying kinase signaling and resistance mechanisms in both cellular and biochemical assays relevant to oncology research.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 890129-26-7
• MW: 578.58
• Purity: >99.99% (May vary between batches)
• Formula: C₃₀H₂₉F₃N₆O₃
• SMILES: CN1CCN(Cc2ccc(NC(=O)c3cccc4cc(Oc5cc(NC(C)=O)ncn5)ccc34)cc2C(F)(F)F)CC1
• Target: CDK,Bcr-Abl
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.91 mM);DMSO:125 mg/mL (216.05 mM)

Bioactivity

• Target IC50:
  c-ABL (T334I):0.25 μM|BCR-ABL (T315I):0.590 μM|BCR-ABL:0.09 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

K0859, K-0859, K03859, K-03859, K 0859, K 03859, inhibit, Inhibitor, Abl (T315I), Abl, BcrAbl, BGG 463, BGG463, BGG-463, c-Abl, Cyclin dependent kinase, CDK

Compound Identifiers

PubChem CID

67406169