Bexarotene

SKU: orb1300792

Description

Bexarotene (LGD1069) is a synthetic retinoid X receptor (RXR) agonist used to treat cutaneous T-cell lymphoma. It is widely employed in oncology research to study its effects on cell proliferation and differentiation in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 153559-49-0
• MW: 348.49
• Purity: >98%
• Formula: C₂₄H₂₈O₂
• SMILES: CC1(C)C=2C(C(C)(C)CC1)=CC(C)=C(C(=C)C3=CC=C(C(O)=O)C=C3)C2
• Target: Retinoid receptor and related
• Solubility: Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 10 mg/ml with warming).

Bioactivity

• In Vivo:
  Bexarotene inhibited the expression of retinoid X receptor alpha and retinoic acid receptor alpha proteins in CTCL cell lines (MJ,HUT78 and 11 h).1 mM and 10 mM Bexarotene treatment of CTCL cell lines (MJ,HUT78 and 11 h) for 96 h increased cellular sub-G1 populations and membrane-bound protein V binding in a dose-dependent manner. Bexarotene treatment reduced the levels of surviving proteins, activated caspase-3 and cleaved poly (ADP-ribose) polymerase, but had no significant effect on the expression of Fas/Fas ligand and bcl-2 proteins in all three CTCL lines.Bexarotene induced a loss of viability and a more pronounced inhibition of clone formation in HH and Hut-78 cells proliferation, while the MJ line showed resistance.
• In Vitro:
  Bexarotene inhibited the expression of retinoid X receptor alpha and retinoic acid receptor alpha proteins in CTCL cell lines (MJ,HUT78 and 11 h).1 mM and 10 mM Bexarotene treatment of CTCL cell lines (MJ,HUT78 and 11 h) for 96 h increased cellular sub-G1 populations and membrane-bound protein V binding in a dose-dependent manner. Bexarotene treatment reduced the levels of surviving proteins, activated caspase-3 and cleaved poly (ADP-ribose) polymerase, but had no significant effect on the expression of Fas/Fas ligand and bcl-2 proteins in all three CTCL lines.Bexarotene induced a loss of viability and a more pronounced inhibition of clone formation in HH and Hut-78 cells proliferation, while the MJ line showed resistance.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LGD-1069; SR-11247

Compound Identifiers

PubChem CID

82146