Fluorobexarotene

SKU: orb1709684

Description

Fluorobexarotene is a potent RXRα agonist with a Ki of 12 nM and an EC50 of 43 nM, exhibiting 75% greater binding affinity than Bexarotene. This small molecule is a valuable research tool for studying RXR-mediated pathways in oncology and metabolic diseases, applicable in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1190848-23-7
• MW: 366.47
• Purity: 99.23%
• Formula: C₂₄H₂₇FO₂
• SMILES: CC1=CC2=C(C=C1C(=C)C1=CC(F)=C(C=C1)C(O)=O)C(C)(C)CCC2(C)C
• Target: Retinoid Receptor
• Solubility: DMSO:5 mg/mL (13.64 mM)

Bioactivity

• Target IC50:
  RXRα:12 nM (Ki)|RXRα:43 nM （EC50）

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RXRα, Retinoid Receptor, RetinoidReceptor, Fluorobexarotene

Compound Identifiers

PubChem CID

25195496