Bevacizumab

• Catalog Number: orb1290240
• Category: Antibodies
• Description: Bevacizumab biosimilar antibody
• Species/Host: Mouse
• Clonality: Monoclonal
• Tested applications: ELISA, FC
• Reactivity: Human
• CAS Number: 216974-75-3
• Isotype: IgG1-kappa
• Antibody Type: Biosimilar Antibody
• Purity: > 95%
• Conjugation: Unconjugated
• Target: VEGFA
• Source: CHO cells
• Biological Activity: Bevacizumab, a humanized monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity, and inhibits its interaction with VEGFR-1 and VEGFR-2. Experimental analysis shows that the EC50 of Bevacizumab to bind VEGF analyzed by ELISA is 0.18 μg/mL. Binding kinetics assays show similar results that Bevacizumab inhibits the VEGF-induced proliferation of HUVEC with an IC50 value of 0.047±0.0081 μg/mL.
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: PBS buffer pH 7.5
• Alternative names: 12-IgG1, F(ab)-12 IgG1, Fab-12 IgG1, rhuMAb-VEGF
• Note: For research use only
• Expiration Date: 12 months from date of receipt.