Betulonic acid

SKU: orb1222252

Description

Betulonic acid amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, which was accompanied by a significant decrease in the severity of liver fibrosis and the absence of cirrhotic transformation of the liver. Betulonic acid derivatives have a promising cytostatic activity in vitro and could be used as potential leads for the development of new type of anti-cancer agents. Betulonic acid has antiholestatic effects in mice.

Key Properties

• CAS Number: 4481-62-3
• MW: 454.69
• Purity: >98% (HPLC)
• Formula: C₃₀H₄₆O₃
• SMILES: CC(=C)C1CCC2(C1C3CCC4C5(CCC(=O)C(C5CCC4(C3(CC2)C)C)(C)C)C)C(=O)O
• Target: Others
• Solubility: DMSO : 6.67 mg/mL 14.67 mM; H2O : < 0.1 mg/mL

Bioactivity

• In Vitro:
  Betulonic acid (72 h) inhibits the growth of various types of human tumor cell lines, including MGC-803, PC3, Bcap-37, A375, MCF-7 tumor cell lines, with IC50s of 17.7, 13.9, 25.7, 28.9, 18.2 μM, respectively. Betulonic acid has antiplasmodial activity, with IC50 of 10 μM. Betulonic acid inhibits HSV-1, ECHO6 and influenza FPV viruses, with EC50s of 0.9, 73.32, and 5.7 μM, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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