beta-Catenin1 (C) Antibody, Rabbit Polyclonal

SKU: orb66707

Description

Rabbit polyclonal to Catenin1 beta.beta-catenin1 is a key downstream effector of the Wnt signaling pathway. It is implicated in earlyembryonic development and tumorigenesis. CK1 phosphorylates beta-catenin1 on Ser45, which primesbeta-catenin1 for subsequent phosphorylation by GSK-3 at Ser33, Ser37 and Thr41. Phosphorylation ofbeta-catenin1 by GSK-3beta leads to its degradation. Wnt signaling antagonizes GSK-3b and stablizes bcatenin1.Mutations in these phosphorylation sites, which result in the stabilization of beta-catenin1protein levels, have been found in many tumor cell lines.

Research Area

Epigenetics, Infectious Diseases, Neuroscience, Signaling Pathways, Wnt

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:5000
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human b-catenin1
• Molecular Weight: 85
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-Catenin1 beta antibody,anti-betacatenin antibody,anti-CTNNB1 antibody,anti-OK antibody,anti-SWcl.35 antibody,anti-CATNB antibody,anti-DKFZp686D02253 antibody,anti-FLJ25606 antibody,anti-FLJ37923 antibody

Western blot analysis of total cell extracts from human MDA-MB231(Lane1) and mouse brain(Lane2) using Catenin1 beta antibody

Quick Database Links

UniProt

P35222