Berbamine

SKU: orb1222215

Description

Berbamine has high binding affinity toward the (GGA);G-quadruplex. Berbamine and its derivatives are promising agents to suppress liver cancer growth by targeting CAMKII. Berbamine may be the first ATP-competitive inhibitor of CaMKII γ, could be as a new type of molecular targeted agent through inhibition of the CaMKII γ activity for treatment of leukemia. 4. Berbamine can enhance the antitumor activity of gemcitabine by inhibiting cell growth and inducing apoptosis, possibly through the regulation of the expression of apoptosis-related proteins and the activation of TGF-β/Smad signaling pathway. Berbamine confers cardioprotection against I/R injury by attenuating [Ca(2+)inf(i) overloading and preventing calpain activation through the activation of the PI3K-Akt-GSK3β pathway and, subsequently, opening of the mitoK(ATP) channel.

Key Properties

• CAS Number: 478-61-5
• MW: 608.73
• Purity: >98% (HPLC)
• Formula: C₃₇H₄₀N₂O₆
• SMILES: CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC
• Target: TRP/TRPV Channel
• Solubility: In Vitro: DMSO : 100 mg/mL (164.28 mM)

Bioactivity

• In Vivo:
  Animal model: Huh7 xenograft NOD/SCID mice model. Dosage: 100 mg/kg. Administration: Oral gavage (p.o.), twice a day for 5 consecutive days. Result: Suppressed tumor growth and reduced tumor weight by 70%.
• In Vitro:
  Cell Viability Assay Cell line: KM3 cell. Concentration: 1 32 μg/mL. Incubation time: 24, 48, or 72 h. Result: Inhibited the growth of KM3 cells in a dose- and time-dependent manner. Apoptosis Analysis Cell line: KM3 cell. Concentration: 4 μg/mL. Incubation time: 6, 12, or 24 h. Result: Induced apoptosis in a time-dependent manner treated at 8 μg/mL. Western blot analysis. Cell line: KM3 cell. Concentration: 8 μg/mL. Incubation time: 0, 6, 12, or 24 h. Result: Inhibited p65 nuclear translocation and expression of IKKα.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TRP/TRPV Channel