Benzyl benzoate

SKU: orb1226803

Description

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 120-51-4
• MW: 212.24
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₂O₂
• SMILES: O=C(OCC1=CC=CC=C1)C2=CC=CC=C2
• Target: Others
• Solubility: Soluble in Water

Bioactivity

• In Vivo:
  Animal model: Hypertensive male Std: ddY mice model. Dosage: 2 mg/kg, 10 mg/kg. Administration: Oral gavage (p.o.); Single dose. Before Ang II treatment (100 μg/kg; Intraperitoneal injection (i.p.); Single dose). Result: Significantly inhibited the rise in systolic blood pressure induced by Ang II treatment. Animal model: Sprague Dawley male rats model. Dosage: 25 mg/kg, 100 mg/kg. Administration: Oral gavage (p.o.); Once daily for 90 days. Result: Induced hepatic portal vein blood supply, sinusoid sinus enlargement, monocyte infiltration, local lysis and cytoplasmic degeneration in rats. Induced renal tissue congestion, renal tubule degeneration, monocyte infiltration and histolysis in rats. Resulted in increased number of Hassall’s bodies, elevated lipids, degeneration, congestion, fibrosis and lymphocytopenia in the thymus of rats. Resulted in vacuolation and irregular secretion of the prostate in male reproductive system tissue, increased connective tissue of the epididymis and presence of cells in the lumen. In the male reproductive system tissues, resulted in vacuolation and irregular secretion in the prostate, increased connective tissue of the epididymis, and presence of cells in the lumen.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Benzyl benzoate

Quick Database Links

Gene Symbol

Others