Belizatinib

SKU: orb1226454

Description

A potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM; exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.Blood Cancer Phase 2 Clinical(In Vitro):TSR-011 has antitumour activity in the clinical trials.(In Vivo):TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.

Key Properties

• CAS Number: 1357920-84-3
• MW: 577.745
• Purity: >98% (HPLC)
• Formula: C₃₃H₄₄FN₅O₃
• SMILES: O=C(NC1=NC2=CC=C(CN3CCC(C(C)(O)C)CC3)C=C2N1[C@H]4CC[C@@H](C(NC(C)C)=O)CC4)C5=CC=C(F)C=C5
• Target: Trk Receptor
• Solubility: DMSO: ≥300 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

• In Vivo:
  TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.
• In Vitro:
  TSR-011 has antitumour activity in the clinical trials.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TSR-011 | TSR011

Quick Database Links

Gene Symbol

Trk Receptor