(E)-Belizatinib

SKU: orb3174572

Description

(E)-Belizatinib ((E)-TSR-011) (compound 36) is the (E)-isomer of Belizatinib, and serves as a potent, highly selective, and orally active inhibitor of anaplastic lymphoma kinase (ALK), with an enzymatic IC50 of 0.005 μM and a cellular IC50 of 0.048 μM. The compound exhibits over 61-fold selectivity against JAK2, SRC, and IGF1R, and demonstrates excellent efficacy and pharmacokinetic properties in rats and dogs. (E)-Belizatinib is applicable for research in ALK-driven cancers.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1388225-72-6
• MW: 577.75
• Formula: C₃₃H₄₄FN₅O₃
• SMILES: N(\C(=O)C1=CC=C(F)C=C1)=C\2/N(C=3C(N2)=CC=C(CN4CCC(C(C)(C)O)CC4)C3)[C@H]5CC[C@@H](C(NC(C)C)=O)CC5
• Target: ALK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ALK