Befiradol hydrochloride

SKU: orb2900804

Description

Befiradol hydrochloride (NLX-112 hydrochloride) is a selective 5-HT1A receptor agonist.

Key Properties

• CAS Number: 2436760-81-3
• MW: 430.32
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₃Cl₂F₂N₃O
• SMILES: Cl.O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(F)(CNCC3=NC=C(C=C3)C)CC2
• Target: 5-HT Receptor
• Solubility: In Vitro: DMSO : 125 mg/mL (290.48 mM; Ultrasonic )

Bioactivity

• In Vivo:
  Befiradol (F13640; NLX-112) reduces the activity of dorsal raphe serotonergic neurons at 0.2-18.2 μg/kg, i. v. (cumulative doses; ED50 = 0.69 μg/kg, i. v.) and increases the discharge rate of 80% of mPFC pyramidal neurons in the same dose range (ED50 = 0.62 μg/kg, i. v.). Both effects are reversed by the subsequent administration of the 5-HT1A receptor antagonist (±)WAY100635. In microdialysis studies, Befiradol (F13640; NLX-112) (0.04-0.63 mg/kg, i.p.) dose-dependently decreases extracellular 5-HT in the hippocampus and mPFC. Likewise, Befiradol (F13640; NLX-112) (0.01-2.5 mg/kg, i.p.) dose-dependently increases extracellular DA in mPFC, an effect dependent on the activation of postsynaptic 5-HT1A receptors in mPFC. Local perfusion of Befiradol in mPFC (1-1, 000 μM) also increases extracellular DA in a concentration-dependent manner. Both the systemic and local effects of Befiradol are prevented by prior (±)WAY100635 administration.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

5-HT Receptor