Befiradol hydrochloride

SKU: orb1687659

Description

Befiradol hydrochloride (NLX-112) is a potent and selective 5-HT1A receptor agonist with demonstrated anxiolytic properties. Research indicates it also reduces mutant ATXN3 protein aggregation, making it a valuable tool for studying serotonin-related neurobiology and spinocerebellar ataxia type 3 in experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2436760-81-3
• MW: 430.32
• Purity: 99.64% (May vary between batches)
• Formula: C₂₀H₂₃Cl₂F₂N₃O
• SMILES: Cl.O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(F)(CNCC3=NC=C(C=C3)C)CC2
• Target: 5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.65 mM);DMSO:43.03 mg/mL (100 mM)

Bioactivity

• In Vivo:
  Befiradol hydrochloride (F13640 hydrochloride; NLX-112 hydrochloride) decreases the activity of dorsal raphe serotonergic neurons when administered intravenously at doses ranging from 0.2 to 18.2 μg/kg, with an effective dose (ED50) of 0.69 μg/kg, i.v. At the same dosage range, it enhances the firing rate of 80% of the medial prefrontal cortex (mPFC) pyramidal neurons, with an ED50 of 0.62 μg/kg, i.v. Befiradol hydrochloride (0.04-0.63 mg/kg; i.p.) dose-dependently decreases extracellular 5-HT in the hippocampus and mPFC. Befiradol hydrochloride (0.01-2.5 mg/kg; i.p.) dose-dependently increases extracellular DA in mPFC, an effect dependent on the activation of postsynaptic 5-HT1A receptors in mPFC. Local perfusion of Befiradol hydrochloride in mPFC (1-1000 μM) also increases extracellular DA in a concentration-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-HT1A, 5HT Receptor, 5HTReceptor, Befiradol Hydrochloride, NLX 112 Hydrochloride, NLX112 Hydrochloride, NLX-112 hydrochloride, NLX-112 Hydrochloride, F 13640 hydrochloride, F 13640 Hydrochloride, F13640 Hydrochloride, F-13640 Hydrochloride

Compound Identifiers

PubChem CID

135397148