Bedaquiline

SKU: orb1305298

Description

Bedaquiline (R207910) is a selective inhibitor of mycobacterial ATP synthase, demonstrating potent activity against both drug-sensitive and drug-resistant Mycobacterium tuberculosis. It is a critical tool for in vitro and in vivo research in microbiology, infectious disease, and antimycobacterial drug discovery.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 843663-66-1
• MW: 555.5
• Purity: >98%
• Formula: C₃₂H₃₁BrN₂O₂
• SMILES: COC1=NC2=C(C=C(C=C2)Br)C=C1[C@@H](C3=CC=CC=C3)[C@](O)(C4=CC=CC5=C4C=CC=C5)CCN(C)C
• Target: Protease
• Solubility: Soluble in DMSO (up to 10 mg/ml)

Bioactivity

• In Vitro:
  Bedaquiline inhibits TDR M. tuberculosis strains with MIC values between 0.125 and 0.5 mg/L. It shows the highest activity against Mycobacterium avium among slowly growing mycobacteria (SGM), with MIC50 and MIC90 values of 0.03 and 16 mg/L. Among rapidly growing mycobacteria (RGM), it is more effective against Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) than Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L. Bedaquiline also exhibits moderate in vitro activity against NTM species and excellent in vitro activity against Mycobacterium tuberculosis, including multidrug-resistant strains.

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TMC207; R207910

Compound Identifiers

PubChem CID

5388906