Bedaquiline fumarate

SKU: orb1306475

Description

Bedaquiline fumarate (TMC207) is a diarylquinoline-class antibiotic that inhibits mycobacterial ATP synthase, blocking its proton pump. It is a first-in-class therapeutic for Mycobacterium tuberculosis, validated in both in vitro assays and in vivo models of tuberculosis infection.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 845533-86-0
• MW: 671.59
• Purity: >99.99% (May vary between batches)
• Formula: C₃₆H₃₅BrN₂O₆
• SMILES: OC(=O)\C=C\C(O)=O.COc1nc2ccc(Br)cc2cc1[C@@H](c1ccccc1)[C@@](O)(CCN(C)C)c1cccc2ccccc12
• Target: Antibacterial,Antibiotic
• Solubility: DMSO:27.5 mg/mL (40.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.98 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TMC 207, TMC207, TMC-207, R 207910, R 403323, R403323, R-403323, R207910, R-207910, inhibit, Inhibitor, Bacterial, Antibiotic, Bedaquiline fumarate, Bedaquiline Fumarate, Bedaquiline

Compound Identifiers

PubChem CID

24812732