BD-AcAc 2

SKU: orb1309937

Description

BD-AcAc 2 is an orally available ketone monoester that elevates blood ketone bodies and other metabolites. It is used in research models to study potential therapeutic applications in sepsis, exercise performance, diabetes, and Parkinson's disease.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1208313-97-6
• MW: 176.21
• Purity: 99.62% (May vary between batches)
• Formula: C₈H₁₆O₄
• SMILES: C[C@@H](O)CCOC(=O)C[C@@H](C)O
• Target: Reactive Oxygen Species,Others
• Solubility: H2O:30 mg/mL (170.25 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (28.38 mM);DMSO:96 mg/mL (544.8 mM)

Bioactivity

• In Vivo:
  BD-AcAc(2) would delay CNS-OT seizures in rats breathing hyperbaric oxygen (HBO(2)). Adult male rats (n = 60) were implanted with radiotelemetry units to measure electroencephalogram (EEG). One week postsurgery, rats were administered a single oral dose of BD-AcAc(2), 1,3-butanediol (BD), or water 30 min before being placed into a hyperbaric chamber and pressurized to 5 atmospheres absolute (ATA) O2 . Beginning at a presymptomatic age, 2 groups of male 3xTgAD mice were fed a diet containing a physiological enantiomeric precursor of ketone bodies (KET) or an isocaloric carbohydrate diet. The results of behavioral tests performed at 4 and 7 months after diet initiation revealed that KET-fed mice exhibited significantly less anxiety in 2 different tests. 3xTgAD mice on the KET diet also exhibited significant, albeit relatively subtle, improvements in performance on learning and memory tests. Immunohistochemical analyses revealed that KET-fed mice exhibited decreased Aβ deposition in the subiculum, CA1, and CA3 regions of the hippocampus, and the amygdala .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(R,R)-Ketone Ester, blood glucose, BD AcAc 2, BDAcAc 2, BD-AcAc 2, diabetes, nutritional ketones, Parkinson's disease, inhibit, muscle weakness, Ketone, Ketone Ester, Inhibitor, exercise performance, endurance, ReactiveOxygenSpecies, Reactive Oxygen Species

Compound Identifiers

PubChem CID

44631890