BD-AcAc 2

SKU: orb1219032

Description

BD-AcAc 2 (Ketone Ester), added in diet, could elevate mean blood ketone bodies of 3.5 mm and lowered plasma glucose, insulin, and leptin in animals.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1208313-97-6
• MW: 176.21
• Purity: >98% (HPLC)
• Formula: C₈H₁₆O₄
• SMILES: C[C@H](CCOC(C[C@@H](C)O)=O)O
• Target: Others
• Solubility: DMSO:96 mg/mL (544.80 mM; Need ultrasonic)；H2O:30 mg/mL (170.25 mM; ultrasonic and heat to 60°C)

Bioactivity

• In Vivo:
  (R, R)-BD-AcAc 2 (D-3HHB) increases specific muscle force, moderately raises blood glucose concentrations, lowers Aldh3b2 gene expression, increases blood Na+ levels and blood creatinine levels, and reduces plasma free fatty acid concentrations. Animal model: Septic mice. Dosage: 10, 20, 40 and 80 mmol/kg/day. Administration: PO. Result: Increased specific muscle force as compared with placebo to 93% of healthy control levels at 40 mmol/kg/day. Resulted in moderately higher blood glucose concentrations as compared with placebo at 40 mmol/kg/day. Lowered Aldh3b2 gene expression than with placebo at 40 mmol/kg/day. Evoked a moderate further increase in blood Na+ levels and increased blood creatinine levels at 20 mmol/kg/day. Reduced plasma free fatty acid concentrations by 10 or 20 mmol/kg/day. Hepatic gene expression levels of Aldh1a7 was also reduced by sepsis but increased by D-3HHB.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ketone Ester

Quick Database Links

Gene Symbol

Others