BAY 593

SKU: orb2695174

Description

BAY 593 is a potent and selective geranylgeranyltransferase-I (GGTase-I) inhibitor that blocks Rho-GTPase activation and downstream YAP1/TAZ signaling. It demonstrates dose-dependent antitumor activity in vitro (IC50: 38.4 nM in MT-1080 cells) and in vivo in xenograft models, supporting its use in cancer research, particularly for studying the Hippo pathway.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2413020-57-0
• MW: 512.99
• Formula: C₂₆H₃₂ClF₃N₂O₃
• SMILES: O(C)C1=C([C@H]2C3(CCN(C([C@](C(F)(F)F)(OC)C4=CC=CC=C4)=O)CC3)CCNC2)C=CC=C1.Cl
• Target: YAP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172652671