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BAY 593

SKU: orb2695174

Description

BAY 593 is a potent and selective geranylgeranyltransferase-I (GGTase-I) inhibitor that blocks Rho-GTPase activation and downstream YAP1/TAZ signaling. It demonstrates dose-dependent antitumor activity in vitro (IC50: 38.4 nM in MT-1080 cells) and in vivo in xenograft models, supporting its use in cancer research, particularly for studying the Hippo pathway.

Research Area

Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number2413020-57-0
MW512.99
FormulaC26H32ClF3N2O3
SMILESO(C)C1=C([C@H]2C3(CCN(C([C@](C(F)(F)F)(OC)C4=CC=CC=C4)=O)CC3)CCNC2)C=CC=C1.Cl
TargetYAP

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

BAY 593 (orb2695174)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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