B-Raf IN 1

SKU: orb1307340

Description

B-Raf IN 1 is a potent dual inhibitor of B-Raf and c-Raf kinases, with IC50 values of 24 nM and 25 nM, respectively. This compound is a valuable research tool for studying MAPK/ERK signaling in cancer biology and for conducting in vitro cellular assays targeting Raf-dependent proliferation.

Research Area

Signal Transduction

Key Properties

• CAS Number: 950736-05-7
• MW: 515.53
• Purity: 97.22% (May vary between batches)
• Formula: C₂₉H₂₄F₃N₅O
• SMILES: CN(C)Cc1ccc(cc1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
• Target: Raf
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (4.85 mM);DMSO:50 mg/mL (96.99 mM)

Bioactivity

• Target IC50:
  B-Raf:24 nM|C-Raf:25 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, B Raf IN 1, BRaf IN 1, B-Raf IN 1, B-Raf, C-Raf, Raf kinases, Raf

Compound Identifiers

PubChem CID

24884503