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B-Raf IN 1

SKU: orb1307340

Description

B-Raf IN 1 is a potent dual inhibitor of B-Raf and c-Raf kinases, with IC50 values of 24 nM and 25 nM, respectively. This compound is a valuable research tool for studying MAPK/ERK signaling in cancer biology and for conducting in vitro cellular assays targeting Raf-dependent proliferation.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number950736-05-7
MW515.53
Purity97.22% (May vary between batches)
FormulaC29H24F3N5O
SMILESCN(C)Cc1ccc(cc1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
TargetRaf
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (4.85 mM);DMSO:50 mg/mL (96.99 mM)

Bioactivity

Target IC50
B-Raf:24 nM|C-Raf:25 nM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, Inhibitor, B Raf IN 1, BRaf IN 1, B-Raf IN 1, B-Raf, C-Raf, Raf kinases, Raf

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

B-Raf IN 1 (orb1307340)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 160.00
1 ml x 10 mM (in DMSO)
$ 180.00
10 mg
$ 250.00
25 mg
$ 400.00
50 mg
$ 550.00
100 mg
$ 740.00
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