Azoramide

SKU: orb1302968

Description

Azoramide is a small-molecule modulator of the unfolded protein response (UPR) with demonstrated antidiabetic properties. It has been utilized in both in vitro and in vivo research to investigate UPR's role in metabolic diseases, including diabetes and hepatic steatosis.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 932986-18-0
• MW: 308.83
• Purity: 99.85% (May vary between batches)
• Formula: C₁₅H₁₇ClN₂OS
• SMILES: CCCC(=O)NCCc1csc(n1)-c1ccc(Cl)cc1
• Target: Mitochondrial Metabolism,ROS,Reactive Oxygen Species,ERK,Bcl-2 Family,Apoptosis,Caspase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.48 mM);DMSO:50 mg/mL (161.9 mM)

Bioactivity

• In Vivo:
  In two independent mouse models of obesity, Azoramide exhibits potent antidiabetic efficacy by improving insulin sensitivity and pancreatic β cell function.
• In Vitro:
  Azoramide, a dual-function endoplasmic reticulum (ER) modulator, improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress in multiple systems.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antidiabetic, Apoptosis, Azoramide, CERB signaling, DA neurons, mitochondrial function, inhibit, ER chaperone capacity, ER protein fold, Inhibitor, PERK, unfolded protein response

Compound Identifiers

PubChem CID

7518316