Azido-PEG10-alcohol

SKU: orb1308599

Description

Azido-PEG10-alcohol is a polyethylene glycol (PEG) linker utilized in constructing PROTAC molecules for targeted protein degradation research. This bifunctional reagent enables the conjugation of warheads to E3 ligase ligands, facilitating the development of degraders for both in vitro biochemical and cellular studies.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 877239-09-3
• MW: 483.55
• Purity: ≥98% (May vary between batches)
• Formula: C₂₀H₄₁N₃O₁₀
• SMILES: C(COCCOCCOCCOCCN=[N+]=[N-])OCCOCCOCCOCCOCCO
• Target: PROTAC Linker
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  PROTACs consist of two distinct ligands linked by a connector: one ligand binds to an E3 ubiquitin ligase, while the other binds to the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PROTAC, PROTAC Linker, PROTAC Linkers, PROTACLinker, PEG, PEGs, tumor, Inhibitor, Linker, inhibit, Azido PEG10 alcohol, AzidoPEG10alcohol, Azido-PEG-10-alcohol, Azido-PEG10-alcohol, cancer

Compound Identifiers

PubChem CID

10896176