Azelaic acid

SKU: orb1226693

Description

Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. It is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 123-99-9
• MW: 188.22
• Purity: >98% (HPLC)
• Formula: C₉H₁₆O₄
• SMILES: OC(=O)CCCCCCCC(O)=O
• Target: DNA/RNA Synthesis
• Solubility: soluble in Water

Bioactivity

• In Vivo:
  Animal model: Human with rosacea for 12 weeks. Dosage: 15% gel. Administration: Smear. Result: Showed excellent improvent in 78% of the patients with Azelaic acid.
• In Vitro:
  Cell Viability Assay Cell line: Propionibacterium acnes and Staphylococcus epidermidis. Concentration: 0.5 M Incubation time: Propionibacterium acnes for 48 h, Staphylococcus epidermidis for 7 D. Result: Exhibited large reduction in viability (at least 40-fold) over 24 h. Immunofluorescence Cell line: HL60, U937, THP-1, and AML-PC cells. Concentration: 5 M. Incubation time: 24 h. Result: Exhibited markedly decreasing the intracellular ROS levels. Cell Viability Assay Cell line: B16, HMB2, and SK23, CHO. Concentration: 10 nM, 20 nM, 30 nM, 40 nM, 50 nM, 60 nM, 70 nM, 80 nM, 90 nM, 100 nM. Incubation time: 24 h. Result: Showed significantly reduce in the number of B16, HMB2, and SK23 comparing to CHO.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 19493

Quick Database Links

Gene Symbol

DNA/RNA Synthesis