Azelaic acid

SKU: orb1310162

Description

Azelaic acid

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 123-99-9
• MW: 188.22
• Purity: 99.89%
• Formula: C₉H₁₆O₄
• SMILES: OC(=O)CCCCCCCC(O)=O
• Target: DNA/RNA Synthesis,Antibiotic,Endogenous Metabolite
• Solubility: Ethanol:35 mg/mL (185.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.63 mM);DMSO:245 mg/mL (1301.67 mM);H2O:34 mg/mL (180.64 mM)

Bioactivity

• In Vivo:
  Azelaic acid exhibits an anti-atherogenic effect. Its athero Protective effect is not related to Changes in plasma lipid content. Azelaic acid supplementation decrease the level of CD68 macrophage marker by 34% ( < .05.
• In Vitro:
  AZ(Azelaic acid) combined with taurine (Tau) show more inhibitory effects in melanocytes tha the treatment of AZ alone. AZ combined with Tau inhibit the melanin production and tyrosinase activity of B16F10 melanoma cells without significant cytotoxicity. Also inhibitory effects after treatment with these combined chemical are stronger than AZ alone on melanogenesi.
• Cell Research:
  B16F10 melanoma cells are seeded at a density of 2.5×105 cells/60 mM culture dish the cells are treated with Azelaic acid combined with Tau for 24 hr the cells pellets are dissolved in 1 N NaOH at 60°C for 1 hr the relative melanin content is determined by measurin the absorbance at 475 nM in ELISA reader. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

ThxR, RNASynthesis, RNA Synthesis, inhibit, Nonanedioic acid, Inhibitor, EndogenousMetabolite, Finacea, Azelaic acid, Azelex, Anchoic acid, DNASynthesis, DNA Synthesis, DNA polymerase I, Endogenous Metabolite

Compound Identifiers

PubChem CID

2266