AZD4320

SKU: orb1308613

Description

AZD4320 is a dual BCL-2/BCL-xL inhibitor with reported IC50 values of 26 nM (KPUM-MS3), 17 nM (KPUM-UH1), and 170 nM (STR-428) in cellular assays. This small molecule is a research tool for studying apoptosis mechanisms and has been utilized in preclinical in vitro cancer models.

Research Area

Cell Biology

Key Properties

• CAS Number: 1357576-48-7
• MW: 945.53
• Purity: 99.71% (May vary between batches)
• Formula: C₄₅H₄₈ClF₃N₄O₇S₃
• SMILES: CN(CCO)CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(CC1)[C@@H](O)c1ccccc1-c1ccc(Cl)cc1
• Target: Bcl-2 Family
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (5.29 mM);DMSO:125 mg/mL (132.2 mM)

Bioactivity

• Target IC50:
  BCL-XL:17 nM(KPUM-UH1 cells)|Bcl-2:17 nM(KPUM-UH1 cells)
• In Vitro:
  AZD4320 shows mostly synergistic, and at least additive, growth inhibitory effects on DEL- and DHL derived cell lines. And it profoundly increases cells undergoing apoptosis in all three cell lines. AZD4320 potently augments the antitumor effect of AZD5153 in double expressing lymphoma (DEL)- and double hit lymphoma (DHL)-derived cell lines in a dose-dependent manner.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZD4320, AZD-4320, AZD 4320, BCL-2, BCL2, Bcl-2 Family, BCLxL, BCL-xL, Inhibitor, inhibit

Compound Identifiers

PubChem CID

86661883