AZD 4320

SKU: orb1941094

Description

AZD4320 is a BH3 mimetic and dual Bcl-2/Bcl-XL inhibitor with IC50 of 24 days) tumor regressions in a mouse RS4;11 acute lymphocytic leukemia xenograft model (20 mg/kg, i.v.).

Key Properties

• CAS Number: 1357576-48-7
• MW: 945.525
• Purity: >98% (HPLC)
• Formula: C₄₅H₄₈ClF₃N₄O₇S₃
• SMILES: O=C(NS(=O)(C1=CC=C(N[C@H](CCN(CCO)C)CSC2=CC=CC=C2)C(S(=O)(C(F)(F)F)=O)=C1)=O)C3=CC=C(N4CCC([C@H](C5=CC=CC=C5C6=CC=C(Cl)C=C6)O)CC4)C=C3
• Target: Bcl-2
• Solubility: In Vitro: DMSO : 100 mg/mL (105.76 mM)

Bioactivity

• In Vitro:
  AZD4320 potently augments the antitumor effect of AZD5153 (Cat. No.: HY-100653A) in double expressing lymphoma (DEL)- and double hit lymphoma (DHL)-derived cell lines in a dose-dependent manner. AZD4320 shows mostly synergistic, and at least additive, growth inhibitory effects on DEL- and DHL derived cell lines, and profoundly increases cells undergoing apoptosis in all three cell lines.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZD4320

Quick Database Links

Gene Symbol

Bcl-2