AZD1208

SKU: orb1305752

Description

AZD1208 is a potent and selective oral inhibitor targeting all three PIM kinase isoforms with nanomolar activity. It has been utilized in preclinical research to investigate oncology pathways, demonstrating effects in both cellular assays and in vivo tumor models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 1204144-28-4
• MW: 379.5
• Purity: >98%
• Formula: C₂₁H₂₁N₃O₂S
• SMILES: NC1CCCN(C1)c1c(\C=C2/SC(=O)NC2=O)cccc1-c1ccccc1
• Target: Kinase
• Solubility: Soluble in DMSO (up to 2 mg/ml) with warming

Bioactivity

• Target IC50:
  Pim3:1.9 nM|Pim2:5 nM|Pim1:0.4 nM
• In Vivo:
  AZD1208 induces cell cycle arrest and apoptosis in cultured MOLM-16 cells, accompanied by a dose-dependent decrease in the phosphorylation of BAD, 4EBP1, and p70S6K. Additionally, AZD1208 effectively inhibits colony growth of primary AML cells derived from bone marrow aspirates and downregulates phosphorylation of Pim targets.
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• In Vitro:
  AZD1208 dose-dependently inhibits the growth of MOLM-16 and KG-1a xenograft tumors in vivo.
• Cell Research:
  AZD1208 is dissolved in DMSO. MOLM-16 cells, purchased from DSMZ and cultured in RPMI containing 10% fetal bovine serum (FBS) and 1% L-glutamine, are plated at 20,000 cells per well in 96 well plates overnight. Cells are treated for 72 hours with compound or control vehicle (dimethyl sulfoxide) and cell viability is measured after the addition of Cell Titer-Blue for 4 hours at 37 C and reading of fluorescence on a Tecan Infinite 200. The GI50 is determined by calculating growth at each dose relative to vehicle treated cells and cell viability at the time of treatment.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pim kinases, Pim1, Pim, Pim2, Pim3, Apoptosis, AZD 1208, Autophagy, AZD1208, AZD-1208, Inhibitor, inhibit

Compound Identifiers

PubChem CID

91827694