AZD1208

SKU: orb1222812

Description

AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Pan-PIM kinase inhibitor AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs. The growth inhibition of several leukemia cell lines by this agent is correlated with the expression levels of PIM1, which is the substrate of STAT transcription factors. PIM kinases are downstream effectors of many cytokine and growth factor signaling pathways and are upregulated in various malignancies.

Key Properties

• CAS Number: 1204144-28-4
• MW: 379.48
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₁N₃O₂S
• SMILES: c1(c(cccc1/C=C/1\SC(=O)NC1=O)c1ccccc1)N1CCC[C@H](C1)N
• Target: Pim1| Pim2| Pim3
• Solubility: DMSO : 28.5 mg/mL 75.10 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZD1208 | AZD-1208

Quick Database Links

Gene Symbol

Pim1| Pim2| Pim3