Azathioprine

SKU: orb1309279

Description

Azathioprine

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 446-86-6
• MW: 277.26
• Purity: 99.90%
• Formula: C₉H₇N₇O₂S
• SMILES: CN1C=NC(=C1SC1=NC=NC2=C1NC=N2)[N+]([O-])=O
• Target: GPCR,Apoptosis,Rho
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.21 mM);DMSO:49 mg/mL (176.73 mM)

Bioactivity

• In Vivo:
  Azathioprine inhibits Rac1 target genes in Primary human CD4+ T lymphocytes, leading to apoptosis vi the mitochondrial pathway. In isolated rat hepatocytes, Azathioprine depletes reduced glutathione (GSH), releases lactate dehydrogenase, and decreases cellular viability.
• In Vitro:
  In murine and rat brain allografts the combination of Azathioprine with Cyclosporin A or Prednisolone significantly enhances survival rates.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

6-Mercaptopurine, Azathioprine, Apoptosis, Autoimmunity inhibitor, BW 57-322, Inhibitor, HGPRT, Infectious skin diseases, inhibit, Rheumatic diseases, Rac1

Compound Identifiers

PubChem CID

2265