Azasetron hydrochloride

SKU: orb1226726

Description

Azasetron Hydrochloride is a 5-HT3 receptor antagonist which is used as an anti-emetic.Azasetron inhibited the specific binding of [3H]quipazine to 5-HT3 receptors at the synaptic membranes of the rat cerebral cortex.(In Vivo):Azasetron could effectively penetrate through the skin and pass into the systemic circulation.

Key Properties

• CAS Number: 123040-16-4
• MW: 386.27
• Purity: >98% (HPLC)
• Formula: C₁₇H₂₀ClN₃O₃·HCl
• SMILES: c1(cc(C(N[C@@H]2CN3CCC2CC3)=O)c2c(c1)N(C)C(=O)CO2)Cl.Cl
• Target: 5-HT Receptor
• Solubility: Water: 3 mg/mL (7.76 mM)

Bioactivity

• In Vivo:
  Azasetron could effectively penetrate through the skin and pass into the systemic circulation. Animal model: Four male Bama miniature pigs weighing 9-11 kg (15-16 weeks old). Dosage: 0.5 mg/kg. Administration: I. V. administration via the abdominal vein. Result: The mean plasma concentration dropped to minimum at 36 h. Cmax = 44.88 ± 7.16 ng/mL) was achieved at the time point of 66.00 ± 22.98 h (Tmax).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Azasetron hydrochloride | Y 25130 | Y-25130 | Y25130.

Quick Database Links

Gene Symbol

5-HT Receptor