Avermectin B1a

SKU: orb1299666

Description

Avermectin B1a is a macrocyclic lactone anthelmintic compound used in research. It is widely applied in parasitology studies for its potent activity against nematodes, serving as a key tool in both in vitro assays and in vivo animal models of helminth infection.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 65195-55-3
• MW: 873.08
• Purity: 95.00%
• Formula: C₄₈H₇₂O₁₄
• SMILES: CC[C@H](C)[C@@H]1[C@H](C=C[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C
• Target: Antibiotic,Parasite
• Solubility: DMSO:255 mg/mL (292.07 mM)

Bioactivity

• In Vitro:
  The binding of the glycine receptor antagonist, strychnine, to both membranes and solubilized receptor from rat spinal cord, was inhibited by avermectin B1a with Ki values of 1.3 microM and 3.6 microM, and Hill coefficients of 0.46 and 0.62, respectively.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antibiotic, Avamectin B1a, Avermectin B1a, Avermectin B-1a, Abamectin B1a, inhibit, Inhibitor, Parasite

Compound Identifiers

PubChem CID

6434889