Avelumab Antibody

SKU: orb1297811

Description

Avelumab is a human IgG1 monoclonal antibody targeting PD-L1, capable of inducing antibody-dependent cellular cytotoxicity (ADCC). It is utilized in research applications, including in vitro immune checkpoint blockade studies and in vivo models investigating its antitumor activity.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 1537032-82-8
• MW: 143.8 kDa
• Purity: 95.00%
• Target: PD-1/PD-L1

Bioactivity

• Animal Research:
  Female C57BL/6 mice are used in this study. Subcutaneous tumor injections are carried out by inoculating C57BL/6 mice with 1×105 MB49 parental cells on the right shaved flank. Tumor growth is measured with calipers and 8 days post-inoculation mice are assigned to treatment groups. Tumor-bearing mice are treated with Avelumab (400 μg per 100 μL) and injected i.p. three times, 3 days apart. Since Avelumab is a human IgG1, three injections have to be compressed within a 7 to 9 day window (i.e., days 9, 12, and 15 post-tumor inoculation) to avoid the onset of neutralizing mouse anti-human Ig.

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, MSB 0010718C, MSB0010718C, inhibit, PD1/PDL1, PD-1, PD1, PD-1/PD-L1, Avelumab, PD-L1, PDL1

Quick Database Links

Gene Symbol

PD-1/PD-L1