Autophinib

SKU: orb1303050

Description

Autophinib

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1644443-47-9
• MW: 346.73
• Purity: 99.41%
• Formula: C₁₄H₁₁ClN₆O₃
• SMILES: Cc1cc(Nc2cc(Cl)nc(Oc3ccc(cc3)[N+]([O-])=O)n2)n[nH]1
• Target: PI3K,Autophagy
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:5 mg/mL (14.42 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  Autophagy:40 nM|VPS34:19 nM
• In Vitro:
  Autophinib targets VPS34 but not other lipid kinases, mTOR and TBK1. Autophinib appears to be ATP-competitive, targets VPS34 in cell lysate and induces cellular phenotypes consistent with VPS34 inhibition. Autophinib inhibits the accumulation of autophagosomes under fed as well as starved conditions, but does not affect the number of autolysosomes. Thus it is not a late stage autophagy inhibitor but an inhibitor of autophagosome formation.
• Cell Research:
  Cell lines: HeLa cellsConcentrations: 30 μMIncubation Time: 18 hMethod:

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, Autophinib, inhibit, Inhibitor, rapamycin-induced autophagy, PI3K, Phosphoinositide 3-kinase, starvation-induced autophagy, VPS34

Compound Identifiers

PubChem CID

129626605