Autophinib

SKU: orb1226000

Description

Autophinib is a novel, potent autophagy inhibitor that inhibits autophagy induced by starvation (IC50=90 nM) or rapamycin (IC50=40 nM) by targeting the lipid kinase VPS34 (IC50=19 nM); inhibits LC3 lipidation to form LC3-II, also inhibits p62 degradation dose-dependently in starved MCF7-LC3 cells; an ATP-competitive inhibitor of VPS34 but not other lipid kinases, mTOR and TBK1.

Key Properties

• CAS Number: 1644443-47-9
• MW: 346.731
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₁ClN₆O₃
• SMILES: O=[N+](C1=CC=C(OC2=NC(Cl)=CC(NC3=NNC(C)=C3)=N2)C=C1)[O-]
• Target: PI3K
• Solubility: DMSO: 64 mg/mL (184.6 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophinib

Quick Database Links

Gene Symbol

PI3K