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Atuzabrutinib

SKU: orb2900946

Description

Atuzabrutinib (SAR 444727) is a potent, selective reversible inhibitor of Btk (Bruton's tyrosine kinase) inhibitor. Atuzabrutinib inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling.

Images & Validation

Key Properties

CAS Number1581714-49-9
MW539.6
Purity>98% (HPLC)
FormulaC30H30FN7O2
SMILESNC1=C2C(N(N=C2C3=C(F)C=C(OC4=CC=CC=C4)C=C3)[C@H]5CN(C(/C(=C/C(C)(C)C)/C#N)=O)CCC5)=NC=N1
TargetBTK
SolubilityIn Vitro: DMSO : 100 mg/mL (185.32 mM; Ultrasonic )

Bioactivity

In Vivo
PRN473 (20 mg/kg) significantly reduces intravascular crawling and neutrophil recruitment into inflamed tissue in a model of sterile liver injury, down to levels seen in Btk-deficient animals.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • Atuzabrutinib [orb1691598]

    99.83% (May vary between batches)

    1581714-49-9

    539.6

    C30H30FN7O2

    1 ml x 10 mM (in DMSO), 100 mg, 25 mg, 1 mg, 10 mg, 5 mg, 50 mg
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Protocol Information

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500 mg
2 mg
$ 440.00
5 mg
$ 680.00
10 mg
$ 1,120.00
25 mg
$ 2,120.00
50 mg
$ 3,560.00
100 mg
$ 5,420.00