Atuzabrutinib

SKU: orb1691598

Description

Atuzabrutinib (SAR 444727) is a selective Bruton's tyrosine kinase (Btk) inhibitor that suppresses neutrophil activation by blocking adhesion receptor signaling. This small molecule is utilized in research models of autoimmune diseases, including rheumatoid arthritis and pemphigus vulgaris, for both in vitro mechanistic studies and in vivo preclinical investigations.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1581714-49-9
• MW: 539.6
• Purity: 99.83% (May vary between batches)
• Formula: C₃₀H₃₀FN₇O₂
• SMILES: NC1=C2C(N(N=C2C3=C(F)C=C(OC4=CC=CC=C4)C=C3)[C@H]5CN(C(/C(=C/C(C)(C)C)/C#N)=O)CCC5)=NC=N1
• Target: BTK
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (6.12 mM);DMSO:80 mg/mL (148.26 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Btk, Atuzabrutinib, PRN473, PRN-473, PRN 473, SAR 444727, SAR444727, SAR-444727

Compound Identifiers

PubChem CID

73438222