Atorvastatin

SKU: orb1306540

Description

Atorvastatin is an oral HMG-CoA reductase inhibitor that lowers lipids via cytochrome P450 activation. It inhibits human SV-SMC cell proliferation and invasion with IC50 values of 0.39 μM and 2.39 μM, respectively. Research applications include studying cardiovascular disease mechanisms and drug interactions, such as a potential pro-thrombotic effect when combined with clopidogrel.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 134523-00-5
• MW: 558.64
• Purity: 99.69% (May vary between batches)
• Formula: C₃₃H₃₅FN₂O₅
• SMILES: C(NC1=CC=CC=C1)(=O)C=2C(=C(N(CC[C@H](C[C@H](CC(O)=O)O)O)C2C(C)C)C3=CC=C(F)C=C3)C4=CC=CC=C4
• Target: Autophagy,HMG-CoA Reductase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.91 mM);DMSO:242.5 mg/mL (434.09 mM)

Bioactivity

• In Vivo:
  Higher dose of atorvastatin can effectively suppress the development and progression of AAA induced by Ang II or CaCl2. Mechanistically, the activation of ER stress and inflammatory response were found involved in Ang II-induced AAA formation. The atorvastatin infusion significantly reduced ER stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice, compared with mice treated by Ang II alone. Furthermore, proinflammatory cytokines such as IL-6, IL-8, IL-1β were all remarkably inhibited after atorvastatin treatment. In vitro, the inhibitory effect of simvastatin on the ER stress signal pathway could be observed in both vascular smooth muscle cells and macrophages, and these inhibitory effects of statin were in a dose-dependent manner. In addition, apoptosis was induced with Ang II treatment. The maximal inhibitory effect of simvastatin on apoptosis was observed at 10 μmol/l.
• In Vitro:
  In the atorvastatin group, myocardial cells were lined up more orderly and myocardial fibrosis level was decreased compared to the model group. The expressions of GRP78, caspase-12 and CHOP in myocardial cells were decreased in atorvastatin group. Moreover, in the atorvastatin-treated group the cell apoptosis rate was reduced and the endoplasmic reticulum (ER) stress was activated in response to heart failure and angiotensin II (Ang II) stimulation

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Atorvastatin, Autophagy, Inhibitor, inhibit, HMGCR, HMG-CoA reductase, HMG-CoA Reductase (HMGCR), HMGCoAReductase, HMGCoA Reductase

Compound Identifiers

PubChem CID

60823