2-Hydroxy atorvastatin calcium salt

SKU: orb1296247

Description

2-Hydroxy atorvastatin calcium salt is a major metabolite of the HMG-CoA reductase inhibitor atorvastatin, exhibiting potent inhibitory activity with an IC50 of 8 nM. This compound is widely used in pharmacological research to study statin metabolism, pharmacokinetics, and efficacy in both in vitro enzyme assays and in vivo animal models of hyperlipidemia.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 265989-46-6
• MW: 1187.341
• Purity: 97.06% (May vary between batches)
• Formula: C₆₆H₆₈CaF₂N₄O₁₂
• SMILES: [Ca++].CC(C)c1c(C(=O)Nc2ccccc2O)c(c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC([O-])=O)-c1ccccc1.CC(C)c1c(C(=O)Nc2ccccc2O)c(c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC([O-])=O)-c1ccccc1
• Target: Drug Metabolite
• Solubility: DMSO:10 mg/mL (16.84 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.68 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2 Hydroxy atorvastatin calcium salt, 2-Hydroxy atorvastatin, 2-Hydroxy atorvastatin calcium, 2Hydroxy atorvastatin calcium salt, Drug Metabolite, DrugMetabolite, inhibit, Inhibitor

Compound Identifiers

PubChem CID

15969744