2-Hydroxy atorvastatin calcium salt

SKU: orb1296247

Description

2-Hydroxy atorvastatin calcium salt is a major metabolite of the HMG-CoA reductase inhibitor atorvastatin, exhibiting potent inhibitory activity with an IC50 of 8 nM. This compound is widely used in pharmacological research to study statin metabolism, pharmacokinetics, and efficacy in both in vitro enzyme assays and in vivo animal models of hyperlipidemia.

Research Area

Metabolism Research

Key Properties

• CAS Number: 265989-46-6
• MW: 593.68
• Purity: 99.92% (May vary between batches)
• Formula: C₃₃H₃₄FN₂O₆ 0.5Ca
• SMILES: [Ca++].CC(C)c1c(C(=O)Nc2ccccc2O)c(c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC([O-])=O)-c1ccccc1.CC(C)c1c(C(=O)Nc2ccccc2O)c(c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC([O-])=O)-c1ccccc1
• Target: Drug Metabolite
• Solubility: DMSO:10 mg/mL (16.84 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.68 mM)

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2 Hydroxy atorvastatin calcium salt, 2-Hydroxy atorvastatin, 2-Hydroxy atorvastatin calcium, 2Hydroxy atorvastatin calcium salt, Drug Metabolite, DrugMetabolite, inhibit, Inhibitor

Compound Identifiers

PubChem CID

15969744