Atopaxar

SKU: orb1705936

Description

Atopaxar (E5555) is a reversible protease-activated receptor-1 (PAR-1) antagonist that inhibits thrombin-mediated platelet aggregation. It has been studied in preclinical and clinical research for the potential management of acute coronary syndrome and coronary artery disease.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 751475-53-3
• MW: 527.63
• Purity: 98.50%
• Formula: C₂₉H₃₈FN₃O₅
• SMILES: CCOc1cc2CN(CC(=O)c3cc(N4CCOCC4)c(OC)c(c3)C(C)(C)C)C(=N)c2c(F)c1OCC
• Target: JAK,Protease-activated Receptor,Apoptosis
• Solubility: DMSO:30 mg/mL (56.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.79 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, platelets, PAR-1, ER-172594-00, Inhibitor, atherothrombotic, Atopaxar, E 5555, E5555, E-5555, receptor-1, receptor, signaling, Protease Activated Receptor (PAR), protease-activated, Protease-Activated Receptor (PAR), Proteaseactivated Receptor, ProteaseactivatedReceptor, thrombin, Thrombin receptors

Compound Identifiers

PubChem CID

10459564