AT-121

SKU: orb1692740

Description

AT-121 is a dual μ-opioid and neuropeptide FF receptor partial agonist with demonstrated in vitro binding and functional activity. In vivo studies in non-human primates show it provides analgesic effects without the reinforcing properties, hyperalgesia, or increased scratching associated with typical opioids, indicating potential as a non-addictive analgesic candidate.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2099681-31-7
• MW: 462.65
• Purity: 99.97% (May vary between batches)
• Formula: C₂₄H₃₈N₄O₃S
• SMILES: O=C1C2(C=3C(CN1CCNS(N)(=O)=O)=CC=CC3)CCN(CC2)[C@@H]4CC[C@H]([C@H](C)C)CC4
• Target: Opioid Receptor
• Solubility: Ethanol:PBS (pH 7.2) (1:20):50 μg/mL;Ethanol:Miscible;DMSO:55 mg/mL (118.88 mM);Chloroform:9 mg/mL (19.45 mM);DMF:Miscible

Bioactivity

• Target IC50:
  μ opioid receptor:16.49 nM(Ki )|Nociception:3.67 nM(Ki )|[35S]-GTPγS:19.6 nM(EC50)|[35S]-GTPγS:34.7 nM(EC50)
• In Vivo:
  AT-121 (0.003-0.03 mg/kg; s.c.; rhesus monkeys) decreases capsaicin-induced thermal allodynia dose-dependently without increasing scratching activity or inducing hyperalgesia, a marker of tolerance development, in doses of 0.01 or 0.03 mg/kg in rhesus monkeys.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

μ-opioid receptor, AT121, AT-121, AT 121, Opioid Receptor, OpioidReceptor

Compound Identifiers

PubChem CID

129188444