AT-121 hydrochloride

SKU: orb1691240

Description

AT-121 hydrochloride is a dual nociceptin and mu opioid receptor agonist (Ki = 3.67 and 16.49 nM, respectively) with demonstrated analgesic and anti-addictive properties in preclinical research. It serves as a valuable tool for investigating non-addictive pain management pathways in both in vitro binding assays and in vivo animal models of nociception and reward.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2099681-71-5
• MW: 499.11
• Purity: 97.28%
• Formula: C₂₄H₃₉ClN₄O₃S
• SMILES: O=C1C2(C=3C(CN1CCNS(N)(=O)=O)=CC=CC3)CCN(CC2)[C@@H]4CC[C@H]([C@H](C)C)CC4.Cl
• Target: Opioid Receptor
• Solubility: DMSO:50 mg/mL (100.18 mM)

Bioactivity

• In Vivo:
  AT-121 hydrochloride (0.003-0.03 mg/kg; s.c.; Adult male and female rhesus monkeys) exhibited dose-dependent antinociceptive effects against acute noxious stimuli, specifically 50 °C water, thereby demonstrating potent antinociceptive activity.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Opioid Receptor, OpioidReceptor, AT 121 hydrochloride, AT 121 Hydrochloride, AT121 hydrochloride, AT121 Hydrochloride, AT-121 Hydrochloride

Compound Identifiers

PubChem CID

146681180