AS601245

SKU: orb1225234

Description

A potent and selective inhibitor of JNK with IC50s of 70/220/150 nM for JNK1/2/3 respectively; less potent for c-Src, c-Raf, p38a; exhibits in vitro and in vivo anti-inflammatory potential.(In Vitro):AS601245, an anti-Inflammatory JNK inhibitor, and Clofibrate have a synergistic effect in inducing cell responses and in affecting the gene expression profile in CaCo-2 colon cancer cells .(In Vivo):AS601245 (40, 60, and 80 mg/kg; i.p.) provides significant protection against the delayed loss of hippocampal CA1 neurons in a gerbil model of transient global ischemia.AS601245 (0.3-10 mg/kg; p.o.) is a potent inhibitor of LPS-induced TNF-α release in mice.

Key Properties

• CAS Number: 345987-15-7
• MW: 372.4462
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₆N₆S
• SMILES: N#C/C(C1=NC(NCCC2=CC=CN=C2)=NC=C1)=C3SC4=CC=CC=C4N\3
• Target: JNK
• Solubility: DMSO: ≥ 35 mg/mL

Bioactivity

• In Vivo:
  Animal model: C3H/HEN mice. Dosage: 0.3, 1, 3, or 10 mg/kg. Administration: p.o. Result: Decreased the TNF-α release in a dose-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AS-601245

Quick Database Links

Gene Symbol

JNK