AS-041164

SKU: orb1306149

Description

AS-041164

Research Area

Signal Transduction

Key Properties

• CAS Number: 6318-41-8
• MW: 249.24
• Purity: 99.59%
• Formula: C₁₁H₇NO₄S
• SMILES: O=C1NC(=O)\C(S1)=C\c1ccc2OCOc2c1
• Target: PI3K
• Solubility: DMSO:125 mg/mL (501.52 mM);10% DMSO+90% Corn Oil:1 mg/mL (4.01 mM)

Bioactivity

• Target IC50:
  PI3Kδ:1.7 μM|PI3Kα:240 nM|PI3Kβ:1.4 μM|PI3Kγ:70 nM
• In Vivo:
  AS-041164 (3-100 mg/kg p.o.) treatment dose-dependently decreases r-h regulated on activation normal T cell expressed and secreted (RANTES)-induced neutrophil recruitment in mice. The ED50 value for AS-041164 is 27.35 mg/kg. AS-041164 blocks RANTES-induced chemotaxis and reduces the level of AKT phosphorylation. AS-041164 (10-100 mg/kg; oral administration; once) treatment results in the reduction of inflammatory swelling in the model of carrageenan-induced paw edema.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AS041164, AS-041164, AS 041164, anti-inflammatory, neutrophil, Inhibitor, inhibit, PI3Kβ, recruitment, PI3Kδ, PI3Kγ, PI3Kα, PI3K, RANTES, Phosphoinositide 3-kinase

Compound Identifiers

PubChem CID

1269519