AS-041164

SKU: orb1217794

Description

AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). It has anti-inflammatory effects.

Key Properties

• CAS Number: 6318-41-8
• MW: 249.24
• Purity: >98% (HPLC)
• Formula: C₁₁H₇NO₄S
• SMILES: O=C(N1)/C(SC1=O)=C/C2=CC=C3C(OCO3)=C2
• Target: PI3K
• Solubility: DMSO:125 mg/mL (501.52 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  AS-041164 (10-100 mg/kg; oral administration; once) treatment results in the reduction of inflammatory swelling in the model of carrageenan-induced paw edema. AS-041164 (3-100 mg/kg p.o.) treatment dose-dependently decreases r-h regulated on activation normal T cell expressed and secreted (RANTES)-induced neutrophil recruitment in mice. The ED50 value for AS-041164 is 27.35 mg/kg. AS-041164 blocks RANTES-induced chemotaxis and reduces the level of AKT phosphorylation. Animal model: Male Wistar rats (100-150 g) injected with carrageenan. Dosage: 10 mg/kg, 30 mg/kg, 100 mg/kg. Administration: Oral administration; once. Result: Induced a significant reduction of paw thickness.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PI3K