ARP-100

SKU: orb1308639

Description

ARP-100 is a potent and selective MMP-2 inhibitor (IC50=12 nM) that binds the S1' pocket, demonstrating anti-invasive activity in Matrigel assays. It shows selectivity over MMP-1, -3, -7, and -9, making it a useful research tool for studying tumor invasion, metastasis, and angiogenesis in cancer models.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 704888-90-4
• MW: 364.42
• Purity: 98.34% (May vary between batches)
• Formula: C₁₇H₂₀N₂O₅S
• SMILES: CC(C)ON(CC(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1
• Target: MMP
• Solubility: DMSO:96 mg/mL (263.43 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.06 mM)

Bioactivity

• Target IC50:
  MMP2:12 nM|MMP7:>50 μM|MMP1:>50 μM|MMP9:0.2 μM|MMP3:4.5 μM
• In Vitro:
  ARP-100 (50 nM) exhibits a significant reduction in the total number of invasive elongations.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Matrix metalloproteinases, matrix, matrigel, inhibit, Inhibitor, invasion, MMP-9, MMP-7, MMP-3, MMP-2 Inhibitor III, MMP-2, MMP-1, MMP, metalloproteinase, ARP 100, ARP100, ARP-100, anti-invasive, selective

Compound Identifiers

PubChem CID

10044321