Aromadendrin

SKU: orb1219408

Description

Aromadendrin is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activityAromadendrin, a flavonol, has been reported to possess a variety of pharmacological activities such as anti-inflammatory, antioxidant, and anti-diabetic properties. Aromadendrin significantly suppressed LPS-induced excessive production of pro-inflammatory mediators such as nitric oxide (NO) and PGE2. In accordance, aromadendrin attenuated LPSinduced overexpression iNOS and COX-2. In addition, aromadendrin significantly suppressed LPS-induced degradation of IκB, which sequesters NF-κB in cytoplasm, consequently inhibiting the nuclear translocation of pro-inflammatory transcription factor NF- κB. Aromadendrin significantly attenuated LPS-induced activation of JNK, but not ERK and p38, in a concentration-dependent manner. Aromadendrin exhibits anti-inflammatory activity through the suppression of nuclear translocation of NF-κB and phosphorylation of JNK in LPS-stimulated RAW 264.7 macrophage cells.

Key Properties

• CAS Number: 480-20-6
• MW: 288.3
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₂O₆
• SMILES: O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC=C(O)C=C3)[C@H]1O
• Target: Bcl-2
• Solubility: DMSO:120 mg/mL (416.31 mM; Need ultrasonic); H2O:< 0.1 mg/mL (insoluble)

Bioactivity

• In Vitro:
  Cell Proliferation Assay Cell line: Normal synoviocyte cells; RA-FLS cells. Concentration: 0.3 μM, 3 μM, 30 μM, 300 μM Incubation time: 48 hours. Result: Decreased the proliferation of RA-FLSs. Apoptosis Analysis Cell line: RA-FLS cells. Concentration: 3 μM, 30 μM. Incubation time: 48 hours. Result: Induced apoptosis in RA-FLSs. Western blot analysis. Cell line: RA-FLS cells. Concentration: 3 μM, 30 μM. Incubation time: 48 hours. Result: Promoted Bax and Bad expression, increased the cleaved fragments of caspase-3, caspase-9 and cleaved PARP and inhibited Bcl-2 and Bcl-xL expression.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Bcl-2