Dihydrokaempferol

SKU: orb1297460

Description

Dihydrokaempferol (Aromadendrin) is a natural flavonoid with demonstrated pro-apoptotic activity via Bcl-2/Bcl-xL downregulation. It exhibits anti-inflammatory, antioxidant, and anti-diabetic properties, supporting its research application in metabolic disease and oncology studies, both in vitro and in animal models.

Research Area

Cell Biology

Key Properties

• CAS Number: 480-20-6
• MW: 288.25
• Purity: 99.96%
• Formula: C₁₅H₁₂O₆
• SMILES: O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c1ccc(O)cc1
• Target: Bcl-2 Family,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.88 mM);H2O:< 0.1 mg/mL (insoluble);DMSO:252.5 mg/mL (875.98 mM)

Bioactivity

• In Vitro:
  Aromadendrin, a flavonol, has been reported to possess a variety of pharmacological activities such as anti-inflammatory, antioxidant, and anti-diabetic properties. Aromadendrin significantly suppressed LPS-induced excessive production of pro-inflammatory mediators such as nitric oxide (NO) and PGE2. In accordance, aromadendrin attenuated LPSinduced overexpression iNOS and COX-2. In addition, aromadendrin significantly suppressed LPS-induced degradation of IκB, which sequesters NF-κB in cytoplasm, consequently inhibiting the nuclear translocation of pro-inflammatory transcription factor NF- κB. Aromadendrin significantly attenuated LPS-induced activation of JNK, but not ERK and p38, in a concentration-dependent manner. Aromadendrin exhibits anti-inflammatory activity through the suppression of nuclear translocation of NF-κB and phosphorylation of JNK in LPS-stimulated RAW 264.7 macrophage cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dihydrokaempferol, Bcl-xL, Bcl-2, Bcl-2 Family, Apoptosis, Aromadendrin, Inhibitor, inhibit, NOS, NO Synthase, PGE

Compound Identifiers

PubChem CID

122850