ARN2966

SKU: orb1299774

Description

ARN2966

Research Area

Neuroscience

Key Properties

• CAS Number: 102212-26-0
• MW: 200.24
• Purity: 99.86%
• Formula: C₁₂H₁₂N₂O
• SMILES: Oc1ccccc1NCc1ccccn1
• Target: Beta Amyloid
• Solubility: DMSO:55 mg/mL (274.67 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.99 mM)

Bioactivity

• In Vivo:
  In vivo,ARN2966 reduces brain levels of full-length APP, α-CTF and β-CTF, and soluble Aβ (1-40) and Aβ (1-42) in the APPSWPS1dE9 transgenic mouse model of Alzheimer's disease. It also improves novel object memory as well as spatial memory in the radial arm maze in APPSWPS1dE9 transgenic mice.
• In Vitro:
  ARN2966 reduces levels of APP and its intracellular C-terminal fragments α-CTF and β-CTF in CHO APP751SW cells when used at a concentration of 10 μM. ARN2966 also reduces secretion of Aβ (1-40) and Aβ (1-42) by 88.6 and 84.9%, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, BetaAmyloid, Beta Amyloid, Abeta, bAmyloid, b Amyloid, ARN 2966, ARN2966, ARN-2966, Amyloid-β, amyloid-β, βAmyloid, β-amyloid peptide, β Amyloid

Compound Identifiers

PubChem CID

14936865